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Shhtm2Chg
Targeted Allele Detail
Nomenclature
Symbol: Shhtm2Chg
Name: sonic hedgehog; targeted mutation 2, Chin Chiang
MGI ID: MGI:3628824
Synonyms: Shhflox, ShhfloxC
Gene: Shh  Location: Chr5:28456840-28467101 bp, - strand  Genetic Position: Chr5, 14.39 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109101
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to flank the sonic hedgehog processing domain in exon 3 with loxP sites. The second loxP site was followed by a Myc epitope tag with a stop codon and an frt-flanked neo cassette downstream of the stop codon. The neo was removed by crossing with mice expressing flp recombinase. (J:109101)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Shh Mutation:  22 strains or lines available
References
Original:  J:109101 Li Y, et al., Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6548-53
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory