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Targeted Allele Detail
Symbol: Del(9Apoa1-Apoa4)1Hmez
Name: deletion, Chr 9, Hafid Mezdour 1
MGI ID: MGI:3628802
Synonyms: Apoa1/Apoc3/Apoa4tm1Hmez, Apoa1/c3/a4-
Gene: Del(9Apoa1-Apoa4)1Hmez  Location: unknown  Genetic Position: Chr9, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:109005
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
  Del(9Apoa1-Apoa4)1Hmez involves 3 genes/genome features (Apoa1, Apoc3, Apoa4) View all
Mutation detailsA neomycin resistance gene replaced the coding sequences of apolipoprotein A-I, apolipoprotein C-III and the first two exons of apolipoprotein A-IV. Northern blot of mutant liver and intestine demonstrated successful ablation of expression of all three genes. Western blot confirmed absence of protein of each gene. (J:109005)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(9Apoa1-Apoa4)1Hmez Mutation:  0 strains or lines available
Original:  J:109005 Mezdour H, et al., Characterization of a new mouse model for human apolipoprotein A-I/C-III/A-IV deficiency. J Lipid Res. 2006 May;47(5):912-20
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory