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Adam1btm1Tba
Targeted Allele Detail
Nomenclature
Symbol: Adam1btm1Tba
Name: a disintegrin and metallopeptidase domain 1b; targeted mutation 1, Tadashi Baba
MGI ID: MGI:3628759
Synonyms: Adam1b-
Gene: Adam1b  Location: Chr5:121500098-121503435 bp, - strand  Genetic Position: Chr5, 61.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109221
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA vector was designed to replace the 455-residue protein-coding region containing the pro-metalloprotease, disintegrin, and cysteine-rich domains at positions 79-533 with a neomycin resistance gene. Absense of transcript was confirmed in Northern blot of mutant testis. Also, protein extracts from testicular germ cells lacked a 120-kDa protein corresponding to the precursor form of Adam1b protein. (J:109221)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam1b Mutation:  14 strains or lines available
References
Original:  J:109221 Kim E, et al., Mouse sperm lacking ADAM1b/ADAM2 fertilin can fuse with the egg plasma membrane and effect fertilization. J Biol Chem. 2006 Mar 3;281(9):5634-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory