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Targeted Allele Detail
Symbol: Prkratm1Gcs
Name: protein kinase, interferon inducible double stranded RNA dependent activator; targeted mutation 1, Ganes C Sen
MGI ID: MGI:3626341
Synonyms: Pact-
Gene: Prkra  Location: Chr2:76629898-76648015 bp, - strand  Genetic Position: Chr2, 45.07 cM
External and internal ear abnormalities in Prkratm1Gcs/Prkratm1Gcs mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:108297
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace about 500 bp of sequence encoding the PKR activation domain in exon 8 with a neomycin resistance cassette. No truncated protein was expressed. The mutant hybrid mRNA was shown to contain 1-22 bases of the endogenous sequence, intron 7, 923-934 of the disrupted exon 8 and the entire neo cassette. (J:108297)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkra Mutation:  10 strains or lines available
Original:  J:108297 Rowe TM, et al., A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5823-8
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.04
The Jackson Laboratory