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Targeted Allele Detail
Symbol: Shox2tm1Ddu
Name: short stature homeobox 2; targeted mutation 1, Denis Duboule
MGI ID: MGI:3626291
Synonyms: Shox2flox, Shox2floxed
Gene: Shox2  Location: Chr3:66971727-66981771 bp, - strand  Genetic Position: Chr3, 30.76 cM, cytoband E3-F1
Limb phenotype of Shox2tm1Ddu/Shox2tm1.1Ddu Tg(Prrx1-cre)1Cjt mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:107668
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites were inserted to flank the entire coding region of the locus. An FRT-flanked neo included in the vector was removed by FLP mediated recombination. (J:107668)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shox2 Mutation:  12 strains or lines available
Original:  J:107668 Cobb J, et al., A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4511-5
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory