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Rasgrp3tm1Jstn
Targeted Allele Detail
Nomenclature
Symbol: Rasgrp3tm1Jstn
Name: RAS, guanyl releasing protein 3; targeted mutation 1, James C Stone
MGI ID: MGI:3625862
Synonyms: Rasgrp3-
Gene: Rasgrp3  Location: Chr17:75435896-75529054 bp, + strand  Genetic Position: Chr17, 46.55 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108677
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P3/J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 2, interrupting the coding sequence downstream of codon 40 in the Ras exchange motif of the catalytic region. (J:108677)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rasgrp3 Mutation:  25 strains or lines available
Notes
ES cell line = NX1.
References
Original:  J:108677 Coughlin JJ, et al., RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. J Immunol. 2005 Dec 1;175(11):7179-84
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory