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Ctsetm1Kjy
Targeted Allele Detail
Nomenclature
Symbol: Ctsetm1Kjy
Name: cathepsin E; targeted mutation 1, Kenji Yamamoto
MGI ID: MGI:3625688
Synonyms: CatE-
Gene: Ctse  Location: Chr1:131638314-131675507 bp, + strand  Genetic Position: Chr1, 57.14 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108745
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced a 3.1-kbp sequence of the gene containing exons 1 to 4. RT-PCR analysis did not detect transcript in spleen tissue from homzygous mutant mice. Immunoblot analysis did not detect protein in homozygous mutant spleen. (J:108745)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctse Mutation:  5 strains or lines available
References
Original:  J:108745 Tsukuba T, et al., Association of cathepsin E deficiency with development of atopic dermatitis. J Biochem. 2003 Dec;134(6):893-902
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory