Cadm1^tm1Mrkm
Targeted Allele Detail

Summary

• Symbol: Cadm1^tm1Mrkm
• Name: cell adhesion molecule 1; targeted mutation 1, Yoshinori Murakami
• MGI ID: MGI:3625113
• Synonyms: Tslc1^-
• Gene: Cadm1 Location: Chr9:47441471-47769413 bp, + strand Genetic Position: Chr9, 25.83 cM, cytoband B-C
• Alliance: Cadm1^tm1Mrkm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108395
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neo cassette replaced exon 1 by homologous recombination. RT-PCR confirmed absence of transcript from exons 1-3 in mutants and Western blot failed to detect protein in mutant testis lysates. (J:108395)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cadm1 Mutation: 39 strains or lines available

References

• Original: J:108395 Yamada D, et al., Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule. Mol Cell Biol. 2006 May;26(9):3610-24
• All: 6 reference(s)