Apoe^tm1Yhg
Targeted Allele Detail

Summary

• Symbol: Apoe^tm1Yhg
• Name: apolipoprotein E; targeted mutation 1, Yadong Huang
• MGI ID: MGI:3624820
• Synonyms: EGFPapoE
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^tm1Yhg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108323
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Coding sequence for EGFP with a stop codon was inserted into the locus immediately after the translation initiation codon in exon 2. A floxed neo was inserted into intron 3. Northern blot showed that the average level of mutant transcript in heterozygotes was 58% of that in wild-type mice. (J:108323)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 145 strains or lines available

References

• Original: J:108323 Xu Q, et al., Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. J Neurosci. 2006 May 10;26(19):4985-94
• All: 2 reference(s)