Gjd3^tm1.1Kwi
Targeted Allele Detail

Summary

• Symbol: Gjd3^tm1.1Kwi
• Name: gap junction protein, delta 3; targeted mutation 1.1, Klaus Willecke
• MGI ID: MGI:3624628
• Synonyms: Cx30.2^fldN
• Gene: Gjd3 Location: Chr11:98873006-98873842 bp, - strand Genetic Position: Chr11, 62.89 cM
• Alliance: Gjd3^tm1.1Kwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108288
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: FLP mediated recombination removed a PGK-neo cassette, leaving the entire coding sequence flanked by loxP sites and a LacZ cassette downstream of the floxed sequence. Endogenous transcript was detected, but at slightly lower levels than wild-type. (J:108288)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gjd3 Mutation: 13 strains or lines available

References

• Original: J:108288 Kreuzberg MM, et al., Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5959-64
• All: 1 reference(s)