Smad4^tm1Rob
Targeted Allele Detail

Summary

• Symbol: Smad4^tm1Rob
• Name: SMAD family member 4; targeted mutation 1, Elizabeth J Robertson
• MGI ID: MGI:3624262
• Synonyms: Smad4^CA, Smad4^f, Smad4^Flox, Smad4^RobCA
• Gene: Smad4 Location: Chr18:73772080-73836851 bp, - strand Genetic Position: Chr18, 49.51 cM
• Alliance: Smad4^tm1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92066
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The first codon was flanked with loxP sites. (J:92066)

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smad4^tm1Rob

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad4 Mutation: 43 strains or lines available

References

• Original: J:92066 Chu GC, et al., Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development. 2004 Aug;131(15):3501-12
• All: 30 reference(s)