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Hipk2tm1Hko
Targeted Allele Detail
Nomenclature
Symbol: Hipk2tm1Hko
Name: homeodomain interacting protein kinase 2; targeted mutation 1, Haruhiko Koseki
MGI ID: MGI:3624127
Synonyms: Hipk2-
Gene: Hipk2  Location: Chr6:38694390-38876165 bp, - strand  Genetic Position: Chr6, 17.85 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106931
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace sequence containing the start codon and the flanking intronic region with the neomycin resistance gene. RT-PCR demonstrated a lack of transcript in mutants. Western blot showed no wild-type protein, but absence of C-terminally truncated proteins could not be concluded. (J:106931)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 20 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hipk2 Mutation:  9 strains or lines available
References
Original:  J:106931 Isono K, et al., Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol. 2006 Apr;26(7):2758-71
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory