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Targeted Allele Detail
Symbol: Prdm9tm1Ymat
Name: PR domain containing 9; targeted mutation 1, Yasuhisa Matsui
MGI ID: MGI:3623909
Synonyms: Meisetz-
Gene: Prdm9  Location: Chr17:15763341-15784616 bp, - strand  Genetic Position: Chr17, 8.95 cM
Germline Transmission:  Earliest citation of germline transmission: J:102875
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector containing the lacZ gene and a loxP-flanked PGKneo cassette disrupted part of exon 2, which contains the initiation codon, all of exons 3 to 6, and part of exon 7. RT-PCR analysis of testes from homozygous mutant mice did not detect transcript. (J:102875)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Prdm9 Mutation:  29 strains or lines available
Original:  J:102875 Hayashi K, et al., A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Nature. 2005 Nov 17;438(7066):374-8
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory