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Crlf2tm1Wjl
Targeted Allele Detail
Nomenclature
Symbol: Crlf2tm1Wjl
Name: cytokine receptor-like factor 2; targeted mutation 1, Warren J Leonard
MGI ID: MGI:3623417
Synonyms: Tslpr-, TSLPR-
Gene: Crlf2  Location: Chr5:109554709-109558993 bp, - strand  Genetic Position: Chr5, 53.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108209
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct was designed to delete all exons of the locus and replace them with a neomycin resistance gene. The inactivation of the gene was confirmed by the defective response of mutant splenocytes compared with wild-type to treatment with anti-CD3 plus TSLP versus anti-CD3 alone. (J:108209)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crlf2 Mutation:  13 strains or lines available
References
Original:  J:108209 Al-Shami A, et al., A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med. 2004 Jul 19;200(2):159-68
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory