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Targeted Allele Detail
Symbol: Ptk2tm1Ilic
Name: PTK2 protein tyrosine kinase 2; targeted mutation 1, Dusko Ilic
MGI ID: MGI:3623143
Synonyms: FAK-
Gene: Ptk2  Location: Chr15:73205105-73423191 bp, - strand  Genetic Position: Chr15, 33.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:24213
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA pgk1-neo cassette lacking a polyA signal was inserted into the exon spanning base pairs 1442 to 1525, which encode the beginning of the kinase domain. Northern blot confirmed absence of normal transcript as well as any truncated transcripts. Western blot failed to detect protein in mutant ES cells. (J:24213)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptk2 Mutation:  60 strains or lines available
Original:  J:24213 Ilic D, et al., Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells. Biochem Biophys Res Commun. 1995 Apr 6;209(1):300-9
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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