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Cln3tm1Mkat
Targeted Allele Detail
Nomenclature
Symbol: Cln3tm1Mkat
Name: ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease); targeted mutation 1, Martin L Katz
MGI ID: MGI:3623134
Gene: Cln3  Location: Chr7:126571207-126585817 bp, - strand  Genetic Position: Chr7, 69.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57155
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced most of exon 7 and all of exon 8. No complete transcript was detected in mutants, however, two smaller mRNA transcripts putatively resulting from alternative splicing around the neo were detected. (J:57155)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cln3 Mutation:  11 strains or lines available
References
Original:  J:57155 Katz ML, et al., A mouse gene knockout model for juvenile ceroid-lipofuscinosis (Batten disease). J Neurosci Res. 1999 Aug 15;57(4):551-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/03/2018
MGI 6.12
The Jackson Laboratory