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Targeted Allele Detail
Symbol: Calcrltm1Kmca
Name: calcitonin receptor-like; targeted mutation 1, Kathleen M Caron
MGI ID: MGI:3623122
Synonyms: Calcrl-
Gene: Calcrl  Location: Chr2:84330626-84425411 bp, - strand  Genetic Position: Chr2, 49.38 cM
Generalized edema in Calcrltm1Kmca/Calcrltm1Kmca, Admtm1Unc/Admtm1Unc, and Ramp2tm1Kmca/Ramp2tm1Kmca mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:106927
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced exons 5 and 6, which includes the translation site, via homologous recombination. Quantitative RT-PCR confirmed absence of RNA. (J:106927)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Calcrl Mutation:  19 strains or lines available
Original:  J:106927 Dackor RT, et al., Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene. Mol Cell Biol. 2006 Apr;26(7):2511-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory