Calcrl^tm1Kmca
Targeted Allele Detail

Summary

• Symbol: Calcrl^tm1Kmca
• Name: calcitonin receptor-like; targeted mutation 1, Kathleen M Caron
• MGI ID: MGI:3623122
• Synonyms: Calcrl^-
• Gene: Calcrl Location: Chr2:84160970-84255755 bp, - strand Genetic Position: Chr2, 49.38 cM
• Alliance: Calcrl^tm1Kmca page

Generalized edema in Calcrl^tm1Kmca/Calcrl^tm1Kmca, Adm^tm1Unc/Adm^tm1Unc, and Ramp2^tm1Kmca/Ramp2^tm1Kmca mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106927
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 5 and 6, which includes the translation site, via homologous recombination. Quantitative RT-PCR confirmed absence of RNA. (J:106927)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Calcrl Mutation: 37 strains or lines available

References

• Original: J:106927 Dackor RT, et al., Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene. Mol Cell Biol. 2006 Apr;26(7):2511-8
• All: 5 reference(s)