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Sp4tm2.1Krc
Targeted Allele Detail
Nomenclature
Symbol: Sp4tm2.1Krc
Name: trans-acting transcription factor 4; targeted mutation 2.1, Kenneth R Chien
MGI ID: MGI:3621971
Synonyms: HF-1b-
Gene: Sp4  Location: Chr12:118234933-118301440 bp, - strand  Genetic Position: Chr12, 63.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107057
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 3 was removed via cre-mediated excision by crossing with Tg(Prm-cre)58Og mice. Semi-quantitative RT-PCR demonstrated a complete deletion of transcript in mutant heart samples. (J:107057)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sp4 Mutation:  15 strains or lines available
References
Original:  J:107057 St Amand TR, et al., Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. Dev Biol. 2006 Mar 15;291(2):208-17
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory