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Targeted Allele Detail
Symbol: Dkk3tm1Cni
Name: dickkopf WNT signaling pathway inhibitor 3; targeted mutation 1, Christof Niehrs
MGI ID: MGI:3621929
Synonyms: Dkk3-
Gene: Dkk3  Location: Chr7:112116017-112159057 bp, - strand  Genetic Position: Chr7, 58.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:106922
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to replace most of exon 2 with an in-frame lacZ and floxed neo cassette. Immunohistochemistry demonstrated that expression in mutants was very weak and limited to the regions of the cerebral cortex. (J:106922)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dkk3 Mutation:  6 strains or lines available
Original:  J:106922 Barrantes Idel B, et al., Generation and characterization of dickkopf3 mutant mice. Mol Cell Biol. 2006 Mar;26(6):2317-26
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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