Parvg^tm1Ref
Targeted Allele Detail

Summary

• Symbol: Parvg^tm1Ref
• Name: parvin, gamma; targeted mutation 1, Reinhard Fassler
• MGI ID: MGI:3621813
• Gene: Parvg Location: Chr15:84208388-84227179 bp, + strand Genetic Position: Chr15, 39.78 cM
• Alliance: Parvg^tm1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106910
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ neo cassette was inserted to replace the 3' end of exon 3 and all of exons 4 through 7. Northern and Western blot failed to detect transcript and protein, respectively, in mutant spleen and thymus samples. (J:106910)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Parvg Mutation: 20 strains or lines available

References

• Original: J:106910 Chu H, et al., gamma-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response. Mol Cell Biol. 2006 Mar;26(5):1817-25
• All: 1 reference(s)