Runx1^{tm1(RUNX1)Gcg}
Targeted Allele Detail

Summary

• Symbol: Runx1^{tm1(RUNX1)Gcg}
• Name: runt related transcription factor 1; targeted mutation 1, Gerard C Grosveld
• MGI ID: MGI:3621479
• Synonyms: MN1-TEL^KI
• Gene: Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
• Alliance: Runx1^{tm1(RUNX1)Gcg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106800
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A fragment of human RUNX1 cDNA containing 62 bp of exon 4 and the rest of the coding region was inserted in-frame into the mouse exon 4. IRES sequences were included upstream of both the MN1-TEL (type 1) and the GFP cDNAs. A stop sequence flanked by loxP sites was located between the RUNX1 and IRES-MN1-TEL cDNAs. (J:106800)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx1 Mutation: 35 strains or lines available

References

• Original: J:106800 Kawagoe H, et al., MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice. Blood. 2005 Dec 15;106(13):4278-86
• All: 2 reference(s)