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Tg(Tcra2C,Tcrb2C)1Dlo
Transgene Detail
Nomenclature
Symbol: Tg(Tcra2C,Tcrb2C)1Dlo
Name: transgene insertion 1, Dennis Y Loh
MGI ID: MGI:3621454
Synonyms: 2C TCR, 2C TCR-Tg
Transgene: Tg(Tcra2C,Tcrb2C)1Dlo  Location: unknown  
Transgene
origin
Strain of Origin:  (C57L x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tcra2C,Tcrb2C)1Dlo expresses 2 genes
 
Mutation detailsThe transgene constructs encode a T cell receptor (TCR) that recognizes the Ld class I major histocompatibility complex (MHC) antigen SIYRYYGL peptide in the context of the H2b MHC class I molecule. Rearranged genomic cosmids containing the entire Tcra and Tcrb coding and promoter regions from the cytotoxic T cell clone 2C were isolated and coinjected into fertilized eggs. Transgenic H2b mice have large numbers of T cells in the periphery that express the transgenic TCR. In the periphery of transgenic H2d mice, T cells expressing the transgenic TCR are deleted. (J:107523, J:120081)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:107523 Sha WC, et al., Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature. 1988 Sep 15;335(6187):271-4
All:  81 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory