Pik3c2b^tm1Pkha
Targeted Allele Detail

Summary

• Symbol: Pik3c2b^tm1Pkha
• Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; targeted mutation 1, Paul A Khavari
• MGI ID: MGI:3621450
• Synonyms: C2beta^fl
• Gene: Pik3c2b Location: Chr1:132973410-133036429 bp, + strand Genetic Position: Chr1, 57.75 cM
• Alliance: Pik3c2b^tm1Pkha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103754
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a loxP-flanked neomycin selection cassette was inserted downstream of exon 5. (J:103754)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3c2b Mutation: 81 strains or lines available

References

• Original: J:103754 Harada K, et al., The class II phosphoinositide 3-kinase C2beta is not essential for epidermal differentiation. Mol Cell Biol. 2005 Dec;25(24):11122-30
• All: 3 reference(s)