Rr320^tm5.1Mkg
Targeted Allele Detail

Summary

• Symbol: Rr320^tm5.1Mkg
• Name: regulatory region 320; targeted mutation 5.1, Mark Groudine
• MGI ID: MGI:3621032
• Synonyms: delta4, Hbb-ar^tm5.1Mkg
• Gene: Rr320 Location: Chr7:103501973-103526752 bp, + strand Genetic Position: Chr7, Syntenic
• Alliance: Rr320^tm5.1Mkg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106655
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The loxP site flanked neomycin resistance gene cassette was removed via cre-mediated excision from Rr320^tm5Mkg, leaving the deletion of 5'HS4 encoded by nucleotides -19849 to -22561 relative to the Ey cap site. (J:106655)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr320 Mutation: 0 strains or lines available

References

• Original: J:106655 Bender MA, et al., Targeted deletion of 5'HS1 and 5'HS4 of the beta-globin locus control region reveals additive activity of the DNaseI hypersensitive sites. Blood. 2001 Oct 1;98(7):2022-7
• All: 2 reference(s)