Tg(GFAP-CDK4)2Gtm
Transgene Detail

Summary

• Symbol: Tg(GFAP-CDK4)2Gtm
• Name: transgene insertion 2, David H Gutmann
• MGI ID: MGI:3620555
• Synonyms: GFAP-hCDK4 transgene
• Transgene: Tg(GFAP-CDK4)2Gtm Location: unknown
• Alliance: Tg(GFAP-CDK4)2Gtm page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(GFAP-CDK4)2Gtm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CDK4 (1019)

  Cdk4	(MGI:88357)

• Mutation details: The transgene comprises a 2.2 kb 5' flanking fragment containing the promoter and upstream regulatory elements of the human glial fibrillary acidic protein gene joined to a 912 bp DNA fragment encoding human CDK4 followed by a 0.5 kb fragment containing an intron and the polyadenylation signal from the mouse protamine 1 gene. RT-PCR demonstrated expression of mRNA and western blot analysis of protein in astrocytes. (J:86020)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This is one of three lines reported; the others are lines 8 and 27. No distinction is made among them in the primary reference.

References

• Original: J:86020 Huang ZY, et al., Astrocyte-specific expression of CDK4 is not sufficient for tumor formation, but cooperates with p53 heterozygosity to provide a growth advantage for astrocytes in vivo. Oncogene. 2002 Feb 21;21(9):1325-34
• All: 1 reference(s)