Tg(CTSG-RARA/PML)2683Ley
Transgene Detail

Summary

• Symbol: Tg(CTSG-RARA/PML)2683Ley
• Name: transgene insertion 2683, Timothy Ley
• MGI ID: MGI:3620139
• Synonyms: HCG-RARalpha-PML transgene, RP2
• Transgene: Tg(CTSG-RARA/PML)2683Ley Location: unknown
• Alliance: Tg(CTSG-RARA/PML)2683Ley page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The functional cDNA coding sequence is derived from the breakpoint cluster region 3 (bcr-3) isoform transcript of the RARA/PML fusion gene resulting from the characteristic t(15;17)(q22;q11.2-q12) translocation associated with ~90% of human cases of acute promyelocytic leukemia (APML). The bcr-3 isoform of the chimeric gene joins exon 2 of the retinoic acid receptor alpha (RARA) gene in-frame to PML exons 4-8. Expression is targeted specifically to early myeloid-lineage cells by the promoter and 5' regulatory elements of the human cathepsin G gene. (J:59080)

Tumor Data

List all tumor models in MMHCdb carrying Tg(CTSG-RARA/PML)2683Ley

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This is one of 4 germline-transmitting lines expressing this transgenic construct that are mentioned in J:59080, of which 2 are characterized in detail (but not distinguished from one another).

Leukemia in the doubly transgenic mice described above is a model for acute promyelocytic leukemia; see OMIM *102578: ACUTE PROMYELOCYTIC LEUKEMIA, INDUCER OF; PML

References

• Original: J:59080 Pollock JL, et al., A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15103-8
• All: 2 reference(s)