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Targeted Allele Detail
Symbol: Mylktm1Avs
Name: myosin, light polypeptide kinase; targeted mutation 1, A V Somlyo
MGI ID: MGI:3620051
Gene: Mylk  Location: Chr16:34745210-35002420 bp, + strand  Genetic Position: Chr16, 24.49 cM
Germline Transmission:  Earliest citation of germline transmission: J:106058
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA targeting vector was designed to remove a 30-nucleotide promoter sequence containing the AT-rich region and the CArG box, resulting in a complete loss of protein. (J:106058)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mylk Mutation:  5 strains or lines available
Original:  J:106058 Khromov AS, et al., Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2440-5
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory