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Dpagt1tm1Jxm
Targeted Allele Detail
Summary
Symbol: Dpagt1tm1Jxm
Name: dolichyl-phosphate N-acetylglucosaminephosphotransferase 1; targeted mutation 1, Jamey Marth
MGI ID: MGI:3620022
Synonyms: GPTdelta
Gene: Dpagt1  Location: Chr9:44237316-44245197 bp, + strand  Genetic Position: Chr9, 24.84 cM
Alliance: Dpagt1tm1Jxm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:59695
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA single loxP site was inserted upstream of exon 1 and and additional loxP-flanked nemoycin/thymidine kinase selection cassette was inserted into intron 2. Transient cre expression in ES cells resulted in the deletion of all intervening sequences, including exons 1-2 and the selection cassette. Heterozygous mice exhibit a decrease in protein activity in livers and mammary gland. (J:59695)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dpagt1 Mutation:  21 strains or lines available
References
Original:  J:59695 Marek KW, et al., A recessive deletion in the GlcNAc-1-phosphotransferase gene results in peri-implantation embryonic lethality. Glycobiology. 1999 Nov;9(11):1263-71
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory