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Targeted Allele Detail
Symbol: Lrp8tm4Her
Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; targeted mutation 4, Joachim Herz
MGI ID: MGI:3619603
Synonyms: Apoer2[Dab-], Apoer2 EIG
Gene: Lrp8  Location: Chr4:107802261-107876840 bp, + strand  Genetic Position: Chr4, 50.18 cM, cytoband C7
Germline Transmission:  Earliest citation of germline transmission: J:105699
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted
Mutation:    Insertion
Mutation detailsA targeting vector was used to change an NFD amino acid sequence beginning at residue 893 to EIG, which disables the protein's ability to interact with disabled homolog 1. GST pull-down experiments confirmed the disruption of this interaction. (J:105699)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp8 Mutation:  5 strains or lines available
Original:  J:105699 Beffert U, et al., Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. J Neurosci. 2006 Feb 15;26(7):2041-52
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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