Miju^C3HeB/FeJ
QTL Variant Detail

Summary

• QTL variant: Miju^C3HeB/FeJ
• Name: modifier of IgJ upregulation; C3HeB/FeJ
• MGI ID: MGI:3619554
• QTL: Miju Location: unknown Genetic Position: Chr12, Syntenic

Variant origin

• Strain of Specimen: C3HeB/FeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased serum IgA levels compared to C57BL/6J. (J:91062)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Animals with this allele in conjunction with the Igj^Mat1 mutation exhibit a 40-fold increase in serum IgJ levels on a C57BL/6J background.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:91062

An ENU-induced mutation resulting in 40-fold increased serum IgA levels mapped to the Igj gene on mouse Chromosome 5. The mutation was created on the C3HeB/FeJ genetic background and is named Igj^Mat1. A modifying locus was mapped using 89 animals from a (C3HeB/FeJ-Igj^Mat1 x C57BL/6J)F2 intercross. 86 single nucleotide polymorphisms were used for linkage analysis. A locus named Miju (modifier of IgJ upregulation) was identified at 58 cM (107.64 Mb) on mouse Chromosome 12 near D12Mit20. Miju contributes to 71% of the phenotypic variance, and together with IgJ^Mat1 account for 91% of the variation. Miju maps to a 0.35 Mb interval between SNPb 3-4-4 and D12Mit8 (58 cM). An attractive candidate gene mapping to this interval is Igh-Ia at 58.5 cM. Crip1 (57.9 cM) and Crip2 (58.7 cM) are also potential candidates. Animals carrying Igj^Mat1 and C3HeB/FeJ-derived alleles at Miju exhibit a 40-fold increase in serum IgA.

References

• Original: J:91062 Schneider B, et al., Synergistic interaction of two independent genetic loci causes extreme elevation of serum IgA in mice. Genes Immun. 2004 Jul;5(5):375-380
• All: 1 reference(s)