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Chemically induced Allele Detail
Symbol: Unc93b13d
Name: unc-93 homolog B1, TLR signaling regulator; triple defect
MGI ID: MGI:3619211
Synonyms: 3d, triple D, Unc93b1m1Btlr
Gene: Unc93b1  Location: Chr19:3985186-3999340 bp, + strand  Genetic Position: Chr19, 3.65 cM
Strain of Origin:  C57BL/6J
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsThis mutation was identified in a screen of progeny of ENU-treated mice for aberrant signal transduction through toll-like receptors (TLR). It substitutes G for A in the 9th of 11 exons, replacing a highly-conserved histidine with a positively-charged arginine at amino acid 412 (H412R), which resides in the ninth of 12 predicted transmembrane domains. (J:86521, J:105484) Additional incidental mutations were detected in sequencing for the causative mutation, Unc93b13d, and may be present in stocks carrying this mutation.
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Unc93b1 Mutation:  29 strains or lines available
Original:  J:105484 Tabeta K, et al., The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol. 2006 Feb;7(2):156-64
All:  68 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
The Jackson Laboratory