Hif1a^tm2Mcs
Targeted Allele Detail

Summary

• Symbol: Hif1a^tm2Mcs
• Name: hypoxia inducible factor 1, alpha subunit; targeted mutation 2, M Celeste Simon
• MGI ID: MGI:3619142
• Synonyms: Hif-1alpha KI
• Gene: Hif1a Location: Chr12:73948149-73994304 bp, + strand Genetic Position: Chr12, 31.99 cM
• Alliance: Hif1a^tm2Mcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105812
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, No functional change)
• Mutation: Insertion
• Mutation details: A cDNA encoding c-Myc epitope tagged Hif1a was fused to the SV40 polyA sequence and was inserted into exon 1 of the locus. This allele was created as a control for MGI:3613538. (J:105812)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hif1a Mutation: 48 strains or lines available

References

• Original: J:105812 Covello KL, et al., HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006 Mar 1;20(5):557-70
• All: 1 reference(s)