Clec4e^tm1Cfg
Targeted Allele Detail

Summary

• Symbol: Clec4e^tm1Cfg
• Name: C-type lectin domain family 4, member e; targeted mutation 1, Consortium for Functional Glycomics
• MGI ID: MGI:3618604
• Synonyms: Clec4e^tm1Psob, Mincle^F, MNA
• Gene: Clec4e Location: Chr6:123258748-123266829 bp, - strand Genetic Position: Chr6, 58.35 cM, cytoband F3
• Alliance: Clec4e^tm1Cfg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136334
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP- flanked neomycin selection cassette was inserted downstream of exon 4 and a loxP site was inserted upstream of exon 3. Transient Cre expression removed the selection cassette, leaving loxP sites flanking exons 3 and 4. The correct targeting of the allele was confirmed through southern blotting and PCR. (J:106419, J:136334)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clec4e Mutation: 24 strains or lines available

References

• Original: J:136334 Wells CA, et al., The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J Immunol. 2008 Jun 1;180(11):7404-13
• All: 2 reference(s)