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Targeted Allele Detail
Symbol: Vezttm1.1Smc
Name: vezatin, adherens junctions transmembrane protein; targeted mutation 1.1, Marie C Simmler
MGI ID: MGI:3618234
Synonyms: Veztdfl
Gene: Vezt  Location: Chr10:93939165-94035817 bp, - strand  Genetic Position: Chr10, 48.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:121686
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis mutation was generated by cre-mediated deletion of both exon 5 and the neomycin selection cassette from the floxed Vezttm1Smc allele. Presence of the same two major bands on immunoblots of brain and testis protein extracts from wild-type and heterozygous mutant mice indicates absence of a protein product from the mutant allele; these bands are twice as intense for wild-type as for mutant samples. (J:121686)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vezt Mutation:  19 strains or lines available
Original:  J:121686 Hyenne V, et al., Conditional knock-out reveals that zygotic vezatin-null mouse embryos die at implantation. Mech Dev. 2007 Jul;124(6):449-62
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory