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Rb1tm1Dwg
Targeted Allele Detail
Nomenclature
Symbol: Rb1tm1Dwg
Name: retinoblastoma 1; targeted mutation 1, David W Goodrich
MGI ID: MGI:3617652
Synonyms: Rb1654, Rb R654W
Gene: Rb1  Location: Chr14:73183673-73325822 bp, - strand  Genetic Position: Chr14, 38.73 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105548
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a R654W substitution into exon 20. A floxed neo in intron 19 was removed via cre mediated recombination. Western blot demonstrated protein levels were approximately the same in mutants and wild-type. (J:105548)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rb1 Mutation:  34 strains or lines available
References
Original:  J:105548 Sun H, et al., An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity. Mol Cell Biol. 2006 Feb;26(4):1527-37
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory