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Gabra1tm2.1Geh
Targeted Allele Detail
Nomenclature
Symbol: Gabra1tm2.1Geh
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1; targeted mutation 2.1, Gregg E Homanics
MGI ID: MGI:3617385
Synonyms: H
Gene: Gabra1  Location: Chr11:42130939-42182930 bp, - strand  Genetic Position: Chr11, 24.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105293
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsSerine at position 270 in exon 8 was replaced by a histidine. Flpe was expressed to remove an FRT-flanked neo from the locus. (J:105293, J:107477)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabra1 Mutation:  4 strains or lines available
References
Original:  J:105293 Homanics GE, et al., A gain-of-function mutation in the GABA receptor produces synaptic and behavioral abnormalities in the mouse. Genes Brain Behav. 2005 Feb;4(1):10-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory