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Srmstm1Sia
Targeted Allele Detail
Nomenclature
Symbol: Srmstm1Sia
Name: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites; targeted mutation 1, Shinichi Aizawa
MGI ID: MGI:3616183
Gene: Srms  Location: Chr2:181205562-181213185 bp, - strand  Genetic Position: Chr2, 103.62 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:20410
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA lacZ gene and neomycin resistance cassette was inserted in to the exon encoding the fourth kinase domain. The lacZ gene was fused in-frame to the endogenous gene. Northern blot analysis demonstrated that no detectable transcript was expressed from this allele, and histochemical staining failed to detect beta-galactosidase in multiple tissues tested. (J:20410)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Srms Mutation:  7 strains or lines available
References
Original:  J:20410 Kohmura N, et al., A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption. Mol Cell Biol. 1994 Oct;14(10):6915-25
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory