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Targeted Allele Detail
Symbol: Apbb1tm1Her
Name: amyloid beta (A4) precursor protein-binding, family B, member 1; targeted mutation 1, Joachim Herz
MGI ID: MGI:3615373
Synonyms: Apbb1tm1Sgnt, Fe65-, p97/60FE65-
Gene: Apbb1  Location: Chr7:105558483-105581653 bp, - strand  Genetic Position: Chr7, 55.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:105160
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace 6.5 kb of sequence with a pol2neo cassette and a lacZ into exon 2. Deleted sequence contained the C-terminal 77 nucleotides of exon 2, intron 2 and the N-terminal 158 nucleotides of exon 3. Protein was not detected by Western blot analysis. (J:105160)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apbb1 Mutation:  25 strains or lines available
Original:  J:105160 Guenette S, et al., Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. EMBO J. 2006 Jan 25;25(2):420-31
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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