Cdkl2^tm1Ito
Targeted Allele Detail

Summary

• Symbol: Cdkl2^tm1Ito
• Name: cyclin dependent kinase like 2; targeted mutation 1, Shigeyoshi Itohara
• MGI ID: MGI:3615307
• Synonyms: Cdk12^LacZ, Cdkl2^tm1(lacZ)Ito
• Gene: Cdkl2 Location: Chr5:92153933-92191742 bp, - strand Genetic Position: Chr5, 45.73 cM
• Alliance: Cdkl2^tm1Ito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105081
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to replace the amino terminal coding exons with a lacZ-neo cassette. X-gal staining detected lacZ expression in cerebral cortex between postnatal days 3 to 7. Northern blot did not detect endogenous transcript in mutant brain samples. (J:105081)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkl2 Mutation: 35 strains or lines available

References

• Original: J:105081 Sassa T, et al., Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus. Cell Tissue Res. 2004 Feb;315(2):147-56
• All: 2 reference(s)