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Transgene Detail
Symbol: Tg(APOA1)427Bres
Name: transgene insertion 427, Jan L Breslow
MGI ID: MGI:3614555
Synonyms: hA-ITg, Tg(OHSA-AI)427
Transgene: Tg(APOA1)427Bres  Location: unknown  
Strain of Origin:  (C57BL/6J x CBA/J)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(APOA1)427Bres expresses 1 gene
Mutation detailsThe transgene construct was composed of a 2.2 kb genomic clone of the human gene and contained 256 bp of 5' sequence. Ten to 50 copies were inserted. The human gene is expressed in liver but not in intestine, testis, or ovary. Average human APOA-I levels are 339mg/dl. (J:94253)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:94253 Walsh A, et al., High levels of human apolipoprotein A-I in transgenic mice result in increased plasma levels of small high density lipoprotein (HDL) particles comparable to human HDL3. J Biol Chem. 1989 Apr 15;264(11):6488-94
All:  12 reference(s)

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MGI 6.14
The Jackson Laboratory