Ret^tm6(RET)Jmi
Targeted Allele Detail

Summary

• Symbol: Ret^tm6(RET)Jmi
• Name: ret proto-oncogene; targeted mutation 6, Jeffrey Milbrandt
• MGI ID: MGI:3614431
• Synonyms: RET51(Cdel)
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^tm6(RET)Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105047
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert human RET9 with a substitution of residues 1063-1072 with residues 1063-1072 of human RET51. This allele has a deletion of residues 1073-1114. Endogenous transcript was not detected in mutants; however, human RET51 transcript was detected. (J:105047)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 53 strains or lines available

References

• Original: J:105047 Jain S, et al., Critical and distinct roles for key RET tyrosine docking sites in renal development. Genes Dev. 2006 Feb 1;20(3):321-33
• All: 1 reference(s)