Plcb1^{Tg(LGB)56Mbal}
Transgenic Allele Detail

Summary

• Symbol: Plcb1^{Tg(LGB)56Mbal}
• Name: phospholipase C, beta 1; transgene insertion 56, Maria Balling
• MGI ID: MGI:3613593
• Synonyms: PLC-beta1betaLG
• Gene: Plcb1 Location: Chr2:134628084-135317178 bp, + strand Genetic Position: Chr2, 65.66 cM
• Alliance: Plcb1^{Tg(LGB)56Mbal} page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Null/knockout)
• Mutation: Insertion
• Mutation details: A transgene expressing goat beta-lactoglobulin inserted into intron 30 of the gene. Approximately 22 copies of the transgene inserted into this site. A mutant transcript consisting of Plcb1 and transgene sequences is detected, but no fusion protein is detectable by western blotting in homozygous mice. (J:93076)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcb1 Mutation: 70 strains or lines available

References

• Original: J:93076 Ballester M, et al., Disruption of the mouse phospholipase C-beta1 gene in a beta-lactoglobulin transgenic line affects viability, growth, and fertility in mice. Gene. 2004 Oct 27;341:279-89
• All: 1 reference(s)