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Ireb2tm1.2Mwh
Targeted Allele Detail
Summary
Symbol: Ireb2tm1.2Mwh
Name: iron responsive element binding protein 2; targeted mutation 1.2, Matthias W Hentze
MGI ID: MGI:3613524
Synonyms: Irp2delta
Gene: Ireb2  Location: Chr9:54771073-54819814 bp, + strand  Genetic Position: Chr9, 29.81 cM
Alliance: Ireb2tm1.2Mwh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104538
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was removed from Ireb2tm1.1Mwh by mating with mice expressing Tg(Pgk1-cre)1Lni, creating a null allele. Removal of exon 3 creates a frameshift with premature termination of translation in exon 4. Western blotting confirmed absence of protein in kidney, duodenum, liver and spleen extracts. (J:103414, J:104538)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ireb2 Mutation:  61 strains or lines available
References
Original:  J:104538 Galy B, et al., Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo. RNA. 2004 Jul;10(7):1019-25
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory