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Nr3c2tm2.1Gsc
Targeted Allele Detail
Nomenclature
Symbol: Nr3c2tm2.1Gsc
Name: nuclear receptor subfamily 3, group C, member 2; targeted mutation 2.1, Gunther Schutz
MGI ID: MGI:3613035
Synonyms: MRnull
Gene: Nr3c2  Location: Chr8:76899442-77245012 bp, + strand  Genetic Position: Chr8, 36.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104549
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCre mediated excision was used to remove exon 3, which which encode the first zinc finger of the mineralocorticoid receptor DNA binding domain. (J:104549)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr3c2 Mutation:  4 strains or lines available
References
Original:  J:104549 Berger S, et al., Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):195-200
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory