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Aqp8tm1Ask
Targeted Allele Detail
Nomenclature
Symbol: Aqp8tm1Ask
Name: aquaporin 8; targeted mutation 1, Alan S Verkman
MGI ID: MGI:3613030
Synonyms: Aqp8-
Gene: Aqp8  Location: Chr7:123462291-123468004 bp, + strand  Genetic Position: Chr7, 67.42 cM, cytoband F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104681
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4-6 were replaced with a neomycin cassette. Northern blot failed to detect transcript and Western blot confirmed the absence of protein in mutant submandibular gland, liver, colon and testes. (J:104681)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp8 Mutation:  3 strains or lines available
References
Original:  J:104681 Yang B, et al., Phenotype analysis of aquaporin-8 null mice. Am J Physiol Cell Physiol. 2005 May;288(5):C1161-70
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory