Adora3^{tm2(ADORA3)Msth}
Targeted Allele Detail

Summary

• Symbol: Adora3^{tm2(ADORA3)Msth}
• Name: adenosine A3 receptor; targeted mutation 2, Mitsuo Satoh
• MGI ID: MGI:3613018
• Synonyms: A3AR^c
• Gene: Adora3 Location: Chr3:105811737-105816244 bp, + strand Genetic Position: Chr3, 46.45 cM, cytoband F3
• Alliance: Adora3^{tm2(ADORA3)Msth} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104495
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector was designed such that the whole intracellular loop regions of the human protein were substituted for the equivalent regions of the mouse protein. RT-PCR detected the chimeric transcript was expressed in the same manner as wild-type transcript in normal mice. Wild-type transcript was not detected in mutants. (J:104495)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adora3 Mutation: 24 strains or lines available

References

• Original: J:104495 Yamano K, et al., Generation of adenosine A3 receptor functionally humanized mice for the evaluation of the human antagonists. Biochem Pharmacol. 2006 Jan 12;71(3):294-306
• All: 1 reference(s)