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Targeted Allele Detail
Symbol: P2rx4tm1Ando
Name: purinergic receptor P2X, ligand-gated ion channel 4; targeted mutation 1, Joji Ando
MGI ID: MGI:3612982
Synonyms: P2rx4-
Gene: P2rx4  Location: Chr5:122707544-122729738 bp, + strand  Genetic Position: Chr5, 62.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:104459
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExons 3-5 were replaced by a neomycin resistance cassette flanked by two loxP sites and the neo cassette was subsequently removed with cre recombinase. Northern blot failed to detect transcript in mutant pulmonary microvessel endothelial cells. Protein was not detected by immunological assay. (J:104459)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any P2rx4 Mutation:  11 strains or lines available
Original:  J:104459 Yamamoto K, et al., Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice. Nat Med. 2006 Jan;12(1):133-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory