Sim1^tm1Jlmd
Targeted Allele Detail

Summary

• Symbol: Sim1^tm1Jlmd
• Name: single-minded family bHLH transcription factor 1; targeted mutation 1, Jacques L Michaud
• MGI ID: MGI:3612969
• Synonyms: Sim1^-, Sim1^tlacz, Sim1^tlz, Sim1-tLZ
• Gene: Sim1 Location: Chr10:50770850-50865248 bp, + strand Genetic Position: Chr10, 24.87 cM, cytoband B3-B4
• Alliance: Sim1^tm1Jlmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104419
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A Pgk-neo/Tau-lacZ cassette was inserted into the locus to replace the initiation codon and the basic and HLH domains. The pattern of lacZ staining in the brain of mutant embryos and newborn mice was comparable to the distribution of the wild-type transcript. (J:104419)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sim1 Mutation: 52 strains or lines available

References

• Original: J:104419 Marion JF, et al., Sim1 and Sim2 are required for the correct targeting of mammillary body axons. Development. 2005 Dec;132(24):5527-37
• All: 8 reference(s)