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Targeted Allele Detail
Symbol: Nkrftm1.1Hjh
Name: NF-kappaB repressing factor; targeted mutation 1.1, Hansjorg Hauser
MGI ID: MGI:3612957
Synonyms: NRF-KO
Gene: Nkrf  Location: ChrX:36887540-36902899 bp, - strand  Genetic Position: ChrX, 21.3 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:104192
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 2 and part of intron 1 including the splice acceptor were deleted via cre mediated recombination. The predicted mRNA would contain just the 5' part of the intron sequence as multiple stop codons in the intron prevent translation of the unspliced mRNA. This potential translation product would have 45 amino acids. Northern blot did not detect transcript in mutants. (J:104192)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkrf Mutation:  3 strains or lines available
Original:  J:104192 Froese N, et al., Innate Immune Responses in NF-{kappa}B-Repressing Factor-Deficient Mice. Mol Cell Biol. 2006 Jan;26(1):293-302
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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