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Targeted Allele Detail
Symbol: Nat1/Nat2tm1Kss
Name: N-acetyl transferase 1; targeted mutation 1, Kim S Sugamori
MGI ID: MGI:3612793
Synonyms: Nat1/2(-), Nat1tm1Kss
Gene: Nat1  Location: Chr8:67490968-67492531 bp, + strand  Genetic Position: Chr8, 33.38 cM, cytoband B3.1
Germline Transmission:  Earliest citation of germline transmission: J:103885
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
Mutation detailsA neomycin resistance gene was inserted to delete ~11 kb of sequence, including the entire coding region of Nat1 and most of the coding region of Nat2. RT-PCR failed to detect transcript of either gene in mutants. (J:103885)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nat1 Mutation:  10 strains or lines available
Original:  J:103885 Sugamori KS, et al., Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice. Mol Pharmacol. 2003 Jul;64(1):170-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory